Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

Mucocutaneous Ulcerations and Pancytopenia due to Methotrexate Overdose

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Methotrexate (MTX) is an antifolic drug used in the treatment of immune-mediated and read more neoplastic diseases.Initiation or dosage changes in MTX therapy can cause mucositis and bone marrow suppression.Skin lesions due to acute MTX toxicity are rare, but they serve as a herald for later-onset pancytopenia.Therefore, identification of those cutaneous lesions might help seattle seahawks socks to initiate rescue strategies at an early stage.

Here we describe a case with mucocutaneous ulcerations and pancytopenia due to overdosed MTX.